Did you know that it is quite easy to make your time on LMF microscopes much more efficient? On most of our microscopes, you will find “ND acquisition” which is a module that allows you to combine various dimensions such as multicolor, time-lapse, z-stacks, and numerous x-y-z positions. Thus, instead of running a time-lapse on one field of view (FOV) overnight, you could run it on 96 wells with 10 FOVs each thus resulting in 960 time-lapse datasets for the same amount of microscope time. Using the Perfect Focus System (PFS) is key to multipoint imaging. To use it, simply manually focus, note your z-value, then turn on PFS, and adjust offset knob to return to your z-value.